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Yayin Fang, Ph.D.
Faculty
Faculty

Yayin Fang, Ph.D.

Professor

CV

Department/Office

  • Biochemistry

School/College

  • College of Medicine

Biography

Dr. Yayin Fang is a Professor in Department of Biochemistry and Molecular Biology of the Howard University, College of Medicine. She is the HUMAA Endowed Founder’s Chair in Basic Science (2015 -2018). She received her MS and Ph.D. degrees, both in Physical Chemistry, from Nankai University, China in 1998 and 2001 respectively. She finished her postdoctoral training with Prof. Eric C. Long and Kenny B. Lipkowitz of Indiana University Purdue University at Indianapolis, focusing on theoretical studies on DNA recognition by metallopeptides (2001-2004), and with Prof A. Keith Dunker of the Indiana University, School of Medicine, focusing on relationships between disordered proteins and alternative splicing (2004-2005). She joined the RCMI program at Howard University in 2005. She started her tenure-track assistant professor position at the Department of Biochemistry and Molecular Biology of the Howard University, College of Medicine in 2012, and received her tenure in 2016. In 2020 she was promoted to the rank of full professor. She has a broad interest in computational approaches on rational drug/material design. As PI, she has been funded by NSF on “RUI-Examination of Molecular Recognition of Amino Acid Based Macromolecular Assembles”, and by Office of Naval Research on “Understanding DNA Cleavage with Organometallic Molecules”. As Co-PI, she has been funded by NSF on “HDR DSC: Collaborative Research: Enrich the Data Science Training of STEM”. The results of her research have been published in over 50 peer-reviewed articles and 3 book chapters.

 

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Education & Expertise

Education

Ph.D

Physical Chemistry
Nankai University

MS

Physical Chemistry
Nankai University

Expertise

Molecular modeling and MD simulation on: DNA recognition, Structure based and ligand-based drug design,Polymeric material design.

Academics

Academics

Molecules and Cells

Dental Biochemistry

General Biochemistry

General Biochemistry Laboratory

Protein Structure and Function

Orientation to Research

Research

Research

Specialty

Computational Biology and Bioinformatics

Funding

  • NIH/NIDCR (R25DE032527) 12/01/2022 - 11/30/2027, Role: Co-PI.
  • NSF (1924092) 10/01/2019 - 09/31/2022, Role: Co - PI.
  • NSF (1708959) 9/01/2017 - 8/31/2022, Role: PI.
  • NIH/NIMHD (2U54MD007597) 06/01/2019 –01/31/2024. Role: Co-I.
  • The Office of Naval Research(N00014-19-1-2602). PI: Yayin Fang. 08/01/2019 - 7/31/2021. Role: PI.
  • The Office of Naval Research(N00014-18-1-2145). 03/01/2018 - 2/28/2020. Role: PI.
  • The Office of Naval Research(N00014-17-1-2105). 03/01/2017 - 08/31/2018. Role: PI.
  • NSF-The Howard University HU ADVANCE-IT Mini Grant. 05/01/2016 – 04/30/2017. Role: PI.
  • NSF-The Howard University HU ADVANCE-IT Mini Grant. 10/01/2014 – 09/30/2015. Role: PI.
  • The Howard University Bridge Funds and Pilot Study Awards Program (BFPSAP). 11/01/2012 – 10/31/2013. Role: PI.
  • HUMAA (Howard University Medicine Alumni Association) Endowed Founder’s Chair in Basic Science, Howard University, College of Medicine, July 2015.

Accomplishments

Accomplishments

OUTSTANDING FACULTY RESEARCHER

OUTSTANDING FACULTY RESEARCHER AWARD, Howard University, College of Medicine, November 17, 2021

HUMAA Endowed Founder’s Chair in Basic Science

HUMAA (Howard University Medical Alumni Association) Endowed Founder’s Chair in Basic Science, Howard University, College of Medicine, July 2015.

Most outstanding Presentation by a Junior Faculty Researcher of Computation & Modeling

Most outstanding Presentation by a Junior Faculty Researcher of Computation & Modeling at the 2014 Howard University Research Day on April 4, 2014.

Related Articles

 

Nida Ali Alsaffar, Yayin Fang, Eric Walters. “Thymoquinone Effect on the Dictyostelium discoideum Model Implicates Functional Roles for Glutathione S-transferases in Eukaryotic Proliferation, Chemotaxis, and Development.” PLOS ONE, 3/1/2023. https://doi.org/10.1371/journal.pone.0282399

 

Jessica L. Fletcher, Grant Mahant, Tyler J. Witzleb, Riley Busche, Yayin Fang, Eugene J. Billiot, Fereshteh H. Billiot, Kevin F. Morris. “NMR Investigation of Counterion Binding to Undecyl LL-Leucinevalanate Micelles.” Journal of Dispersion Science and Technology, 12/13/2022. https://doi.org/10.1080/01932691.2022.2145303

 

Patrice Moss, Galina Talanova, Yayin Fang, Courtney Thomas. “Spectroscopic studies of 7,8-diacetoxy-4-methylcoumarin and 7,8-dipentynoyl-4-methylcoumarin binding with Calreticulin” The Journal of Biological and Chemical Luminescence, 2022,1,11. https://doi.org/10.1002/bio.4362

 

Raina Rhoades, Brianna Henry, Dominique Prichett, Yayin Fang, Shaolei Teng. “Computational Saturation Mutagenesis to Investigate the Effects of Neurexin-1 Mutations on AlphaFold Structure” Genes, 2022, 13, 789.

 

Kevin F. Morris, Riley Geoghegan, Emily Palmer, Matthew George, Jr. and Yayin Fang*.  "Molecular Dynamics Simulation Study of AG10 and Tafamidis Binding to the Val122Ile Transthyretin Variant." Biochemistry and Biophysics Reports, 2020, 21, 100721.

 

Kevin F. Morris, Eugene J. Billiot, Fereshteh H. Billiot, Jordan A. Ingle, Kevin B. Krauss, Corbin R. Lewis, Kenny B. Lipkowitz, William M. Southerland, and Yayin Fang*. “Using Molecular Dynamics Simulations to Identify the Key Factors Responsible for Chiral Recognition by an Amino Acid-based Molecular Micelle.” Journal of Dispersion Science and Technology, 2019, 40(5), 716-727.

 

Kevin F. Morris, Eugene J. Billiot, Fereshteh H. Billiot, Jordan A. Ingle, Stephanie R. Zack, Kevin B. Krauss, Kenny B. Lipkowitz, William M. Southerland, and Yayin Fang*. “Investigation of Chiral Recognition by Molecular Micelles with Molecular Dynamics Simulations.” Journal of Dispersion Science and Technology, 2018, 39(1), 45-54.

 

Linyong Mao, Yayin Fang, Michael Campbell, and William M. Southerland. “Population Differentiation in Allele Frequencies of Obesity-Associated SNPs.” BMC medicinal Genomics, 2017, 18 (1), 861-876.

 

Kevin F. Morris, Eugene J. Billiot, Fereshteh H. Billiot, Kenny B. Lipkowitz, William M. Southerland, Yayin Fang*, " Molecular Dynamics Simulation and NMR Investigation of the Association of the β-Blockers Atenolol and Propranolol with a Chiral Molecular Micelle. ", 2015, Chemical Physics, 457, 133-146.

 

Kevin F. Morris, Eugene J. Billiot, Fereshteh H. Billiot, Kenny B. Lipkowitz, William M. Southerland, Yayin Fang*, " A Molecular Dynamics Simulation Study of the Association of 1,1′-Binaphthyl-2,2′-diyl hydrogen phosphate Enantiomers with a Chiral Molecular Micelle.", 2014, Chemical Physics, 439, 36-43

 

Kevin F. Morris, Eugene J. Billiot, Fereshteh H. Billiot, Kenny B. Lipkowitz, William M. Southerland, Yayin Fang*, "A Molecular Dynamics Simulation Study of Two Dipeptide Based Molecular Micelles: Effect of Amino Acid Order ", 2013, Open Journal of Physical Chemistry, 3, 20-29

 

Kevin F. Morris, Eugene J. Billiot, Fereshteh H. Billiot, Kenny B. Lipkowitz, William M. Southerland, Yayin Fang*, "Investigation of Chiral Molecular Micelles by NMR Spectroscopy and Molecular Dynamics Simulation", 2012, Open Journal of Physical Chemistry, 2, 240-251

 

Patrice L. Jackson, K.R. Scott, William M. Southerland, and Yayin Fang*, “Enaminones 8:  CoMFA and CoMSIA Studies on Some Anticonvulsant Enaminones”, Bioorganic & Medicinal Chemistry, 2009, 17, 133-140

 

Pedro R. Romero, Saima Zaidi, Yayin Fang, Vladimir N. Uversky, Predrag Radivojac, Christopher J. Oldfield, Marc S. Cortese, Megan Sickmeier, Tanguy LeGall, Zoran Obradovic and A. Keith Dunker, “Alternative Splicing in Concert with Protein Intrinsic Disorder Enables Increased Functional Diversity in Multicellular Organisms”, Proceedings of the National Academy of Sciences of the United States of America; 2006, 103(22), 8390-8395

 

Yayin Fang; Kenny B. Lipkowitz and Eric C. Long, “Molecular Dynamics Simulations of the Orientation of Ni(II)Gly-Gly-His and Ni(II) •Arg-Gly-His Metallopeptide-DNA Association”, Journal of Chemical Theory and Calculation, 2006, 2(5); 1453-1463

 

Yayin Fang; Craig A. Claussen; Kenny B. Lipkowitz and Eric C. Long, "Diastereoselective DNA Cleavage Recognition by Ni(II)•Gly-Gly-His Derived Metallopeptides",  Journal of the American Chemical Society, 2006, 128(2), 3198 – 3207

 

Yayin Fang, Bruce D. Ray, Craig A. Claussen, Kenny B. Lipkowitz and Eric C. Long,  "Ni(II)·Gly-Gly-His Derived Metallopeptide-DNA Interactions: Structural Characterization of Minor Groove Binding and Recognition",  Journal of the American Chemical Society, 2004, 126(17), 5403 – 5412.

 

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