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Timothy R. Ramadhar

Assistant Professor

  • Chemistry
  • College of Arts & Sciences

Education & Expertise


Chemical Biology (Natural Products), Crystallography

Postdoctoral Fellowship
Harvard Medical School

Chemistry (Organic)

University of Toronto

Honours Biochemistry

University of Waterloo


Organic Chemistry (Synthetic and Computational)

Natural Products

Chemical Crystallography



Organic Chemistry Lecture I

Organic Chemistry Lecture II

Organic Chemistry Laboratory

General Chemistry Laboratory I

General Chemistry Laboratory II




Pfizer, Inc.



Selected Awards

NIH Ruth L. Kirschstein National Research Service Award (F32 Postdoctoral Fellowship Grant)

Grant Numbers: Year 1: 1F32GM108415-01A1 | Year 2: 5F32GM108415-02Granting Institute: National Institute of General Medical Sciences (NIGMS) 

Natural Science and Research Engineering Council (NSERC) of Canada Alexander Graham Bell Canada Graduate Scholarship D3 (CGS D3)

NSERC Canada Graduate Scholarship M (CGS M)

Related Articles

Application of Crystalline Matrices for the Structural Determination of Organic Molecules

Cardenal, A. D.; Ramadhar, T. R.* ACS Cent. Sci. 2021, ASAP, DOI: 10.1021/acscentsci.0c01492. Link

A conserved coccidian gene is involved in Toxoplasma sensitivity to the anti-apicomplexan compound, tartrolon E

Bowden, G. D.; Reis, P. M.; Rogers, M. B.; Bone Relat, R. M.; Brayton, K. A.; Wilson, S. K.; Di Genova, B. M.; Knoll, L. J.; Nepveux, F. J., V; Tai, A. K.; Ramadhar, T. R.; Clardy, J.; O'Connor, R. M.* Int. J. Parasitol. Drugs Drug Resist. 2020, 14, 1–7. Link

A Symbiotic Bacterium of Shipworms Produces a Compound with Broad Spectrum Anti-apicomplexan Activity

O'Connor, R. M.; Nepveux, F. J., V; Abenoja, J.; Bowden, G.; Reis, P.; Beaushaw, J.; Bone Relat, R. M.; Driskell, I.; Giminez, F.; Riggs, M. W.; Schaefer, D. A.; Schmidt, E. W.; Lin, Z.; Distel, D. L.; Clardy, J.; Ramadhar, T. R.; Allred, D. R.; Fritz, H. M.; Rathod, P.; Chery, L.; White, J. PLOS Pathogens 2020, 16, e1008600. Link

GABA-modulating bacteria of the human gut microbiota

Strandwitz, P.;‡ Kim, K. H.;‡ Terekhova, D.; Liu, J. K.; Sharma, A.; Levering, L.; McDonald, D.; Dietrich, D.; Ramadhar, T. R.; Lekbua, A.; Mroue, N.; Liston, C.; Stewart, E. J.; Dubin, M. J.; Zengler, K.; Knight, R.; Gilbert, J. A.; Clardy, J.; Lewis, K.* Nat. Microbiol. 2019, 4, 396. Link

Tundrenone: An Atypical Secondary Metabolite from Bacteria with Highly Restricted Primary Metabolism

Puri, A. W.;‡ Mevers, E.;‡ Ramadhar, T. R.;‡ Petras, D.; Liu, D.; Piel, J.; Dorrestein, P. C.; Greenberg, E. P.; Lidstrom, M. E.; Clardy, J.* J. Am. Chem. Soc. 2018, 140, 2002–2006. (‡ - Equal First Authorship)  Link

Sequential O-Arylation/Lanthanide(III)-Catalyzed [3,3]-Sigmatropic Rearrangement of Bromo-Substituted Allylic Alcohols

Ramadhar, T. R.; Kawakami, J.; Batey, R. A.* Synlett 2017, 28, 2865–2870. (Contribution to a special issue dedicated to the 80th birthday of Prof. Victor A. Snieckus) Link

The Crystalline Sponge Method: A Solvent-Based Strategy to Facilitate Noncovalent Ordered Trapping of Solid and Liquid Organic Compounds

Ramadhar, T. R.;* Zheng, S.-L.; Chen, Y.-S.; Clardy, J.* CrystEngComm 2017, 19, 4528–4534. (Co-corresponding first author) Link

Macrotermycins A–D, Glycosylated Macrolactams from a Termite-Associated Amycolatopsis sp. M39

Beemelmanns, C.;‡* Ramadhar, T. R.;‡ Kim, K. H.;‡ Klassen, J. L.; Cao, S.; Wyche, T. P.; Hou, Y.; Poulsen, M.; Bugni, T. S.; Currie, C. R.; Clardy, J.* Org. Lett. 2017, 19, 1000–1003. (‡ - Equal First Authorship) Link

Homodimericin A: A Complex Hexacyclic Fungal Metabolite

Mevers, E.; Saurí, J.; Liu, Y.; Moser, A.; Ramadhar, T. R.; Varlan, M.; Williamson, R. T.; Martin, G. E.; Clardy, J.* J. Am. Chem. Soc. 2016, 138, 12324–12327. Link

Variable Genetic Architectures Produce Virtually Identical Molecules in Bacterial Symbionts of Fungus-Growing Ants

Sit, C. S.;‡ Ruzzini, A. C.;‡ Van Arnam, E. B.; Ramadhar, T. R.; Currie, C. R.; Clardy, J.* Proc. Natl. Acad. Sci. USA 2015, 112, 13150–13154. (Open Access) Link

Small Molecule Reactivation of Mutant p53 to wt-like p53 through the p53-Hsp40 Regulatory Axis

Hiraki, M.;‡ Hwang, S.-Y.;‡ Cao, S.;‡ Ramadhar, T. R.; Byun, S.; Yoon K. Y.; Lee, J. H.; Chu, K.; Gurkar, A. U.; Kolev, V.; Zhang, J.; Namba, T.; Murphy, M. E.; Newman, D. J.; Mandinova, A.; Clardy, J.;* Lee, S. W.* Chem. Biol. 2015, 22, 1206–1216. Link

Identification of a Dual Inhibitor of Janus Kinase 2 (JAK2) and p70 Ribosomal S6 Kinase1 (S6K1) Pathways

Byun, S.; Lim, S.; Mun, J. Y.; Kim, K. H.; Ramadhar, T. R.; Farrand, L.; Shin, S. H.; Thimmegowda, N. R.; Lee, H. J.; Frank, D. A.; Clardy, J.,* Lee, S. W.,* Lee, K. W.* J. Biol. Chem. 2015, 290, 23553–23562. Link

The Crystalline Sponge Method: MOF Terminal Ligand Effects

Ramadhar, T. R.; Zheng, S.-L.; Chen, Y.-S.; Clardy, J.* Chem. Commun. 2015, 51, 11252–11255. (Open Access) LinkFeatured in an RSC Chemistry World Magazine Article: "Confronting the Crystalline Sponge"​ (June 24, 2015)

Analysis of Rapidly Synthesized Guest-Filled Porous Complexes with Synchrotron Radiation: Practical Guidelines for the Crystalline Sponge Method

Ramadhar, T. R.; Zheng, S.-L.; Chen, Y.-S.; Clardy, J.* Acta Cryst. 2015, A71, 46–58. (Open Access) LinkInterviewed for an article in ACS Chemical and Engineering News (C&EN) Magazine: "Crystalline Sponges Catching on with Chemists"​ (Vol 93, Issue 7, pages 29-30, Feb. 16, 2015) Featured on the "​In the Pipeline"​ blog in a post titled "Guidelines for MOF Crystallography"​ (December 12, 2014) and mentioned again in "X-ray Sponges Ride Again"​ (June 15, 2015)Gave commentary on Prof. Fujita's Chem. Sci. article (2015, 6, 3765-3768) in an RSC Chemistry World magazine story: "Crystalline sponge method strikes again"​ (May 26, 2015)​Gave commentary on Prof. Fujita's J. Am. Chem. Soc. article (2016, 138, 32, 10140–10142) in an RSC Chemistry World magazine story: "Explosive intermediates muzzled by crystalline sponge" (August 24, 2016)

The Crystalline Sponge Method: Synthetic and Crystallographic Guidelines ***Published Conference Abstract***

Ramadhar, T.; Zheng, S.-L.; Chen, Y.-S.; Clardy, J.* Acta Cryst. 2014, A70, C1784 (Published conference abstract for IUCr2014 in Montréal, Québec, Canada, August 5–12, 2014). Link

Natalamycin A, an Ansamycin from a Termite-Associated Streptomyces sp.

Kim, K. H.;‡ Ramadhar, T. R.;‡ Beemelmanns, C.;‡ Cao, S.; Poulsen, M.; Currie, C. R.; Clardy, J.* Chem. Sci. 2014, 5, 4333–4338. (‡ - Equal First Authorship) Link

Bacterial Symbionts in Agricultural Systems Provide a Strategic Source for Antibiotic Discovery

Ramadhar, T. R.; Beemelmanns, C.; Currie, C. R.; Clardy, J.* J. Antibiot. 2014, 67, 53–58 (Review article, contribution to a special issue dedicated to Prof. Christopher T. Walsh). Link

Mild Double Allylboration Reactions of Nitriles and Acid Anhydrides Using Potassium Allyltrifluoroborate

Ramadhar, T. R.; Bansagi, J.; Batey, R. A.* J. Org. Chem. 2013, 78, 1216–1221. Link

Recent Advances in Nucleophilic Addition Reactions of Organoboronic Acids and their Derivatives to Unsaturated C–N Functionalities

Ramadhar, T. R.; Batey, R. A.* in Boronic Acids: Preparation and Applications in Organic Synthesis, Medicine and Materials, Second Edition. Hall, D.G. Ed. Wiley-VCH: Weinheim, Germany. 2011, Chapter 9, pp. 427–477. (Book chapter) Link

Accurate Prediction of Experimental Free Energy of Activation Barriers for the Aliphatic-Claisen Rearrangement through DFT Calculations

Ramadhar, T. R.;* Batey, R. A.* Comp. Theor. Chem. 2011, 976, 167–182. (First co-corresponding author) Link

Resolving the Mechanistic Origins of E/Z-Selectivity Differences for the Aryl-Claisen Rearrangement through DFT Calculations

Ramadhar, T. R.; Batey, R. A.* Comp. Theor. Chem. 2011, 974, 76–78. Link

Allylation of Imines and their Derivatives with Organoboron Reagents: Stereocontrolled Synthesis of Homoallylic Amines

Ramadhar, T. R.; Batey, R. A.* Synthesis 2011, 1321–1346. (Review article) Link

Stereocontrolled Synthesis of Contiguous C(sp3)-C(aryl) Bonds by Lanthanide(III)-Catalyzed Domino Aryl-Claisen [3,3]-Sigmatropic Rearrangements

Ramadhar, T. R.; Kawakami, J.; Lough, A. J.; Batey, R. A.* Org. Lett. 2010, 12, 4446–4449. Link

Cyclobutanone Mimics of Penicillins: Effects of Substitution on Conformation and Hemiketal Stability

Johnson, J. W.; Evanoff, D. P.; Savard, M. E.; Lange, G.; Ramadhar, T. R.; Assoud, A.; Taylor, N. J.; Dmitrienko, G. I.* J. Org. Chem. 2008, 73, 6970–6982. Link

Inverse H-C ex situ HRMAS NMR Experiments for Solid-Phase Peptide Synthesis

Ramadhar, T. R.; Amador, F.; Ditty, M. J. T.; Power, W. P.* Magn. Reson. Chem. 2008, 46, 30–35. Link