Associate Professor and Associate Chair
- College of Arts & Sciences
Education & Expertise
Gyeongsang National University
Cold Spring Harbor Laboratory
Protein Structure Modeling
Bioinformatics (BIOL/BIOG 419)
Biostatistics (BIOL/BIOG 430)
Bioinformatics is a new scientific discipline that utilizes computational approaches for understanding the biological meanings behind the large amounts of complex data generated from high-throughput technologies. The goal of the Teng lab is to develop and apply bioinformatics approaches for analyzing the genetic variations associated with human diseases and discovering biological knowledge hidden in the massive data sets. We are currently focused on three research areas including next-generation sequencing, machine learning and protein structure modeling.
NEXT-GENERATION SEQUENCING (NGS) technologies make the sequencing much faster and cheaper, which have revolutionized genetic research and accelerated precision medicine. We are using whole genome sequencing and targeted sequencing to identify the sequence variants that contribute to major psychiatric disorders including schizophrenia, bipolar disorder and major depressive disorder. We are applying RNA sequencing to study gene expression changes in model organisms. In addition, we are developing bioinformatics tools and databases to analyze NGS data for mental illness and cancer research.
MACHINE LEARNING can recognize complex and hidden pattern from massive data sets, and it is particularly appealing for biological knowledge discovery in big data. We are developing new machine learning methods to analyze NGS data, disease-causing mutations and protein post-translational modifications.
PROTEIN STRUCTURE MODELING provides an efficient and accurate way to investigate the functional effects of coding sequence variants by mapping them on the corresponding structure models. We are using homology modeling and energy calculation approaches to estimate the effects of missense variants on protein stability and protein-protein interactions, and investigate the roles of the mutations in complex diseases such as obesity, cancers and psychiatric disorders.
Modeling effects of human SNPs on protein-protein interactions
Shaolei Teng, Petras Kundrotas, Thomas Madej, Anna Panchenko and Emil Alexov. (2009) Modeling effects of human SNPs on protein-protein interactions. Biophysical Journal 96(6): 2178-2188.
Rare disruptive variants in the DISC1 Interactome and Regulome
S Teng, PA Thomson, S McCarthy, M Kramer, S Muller, J Lihm, S Morris, Rare disruptive variants in the DISC1 Interactome and Regulome: association with cognitive ability and schizophrenia. Molecular psychiatry 23 (5), 1270
Electrostatic force differences caused by mutations in kinesin motor domains can distinguish ...
L Li, Z Jia, Y Peng, S Godar, I Getov, S Teng, J Alper, E Alexov. Forces and Disease: Electrostatic force differences caused by mutations in kinesin motor domains can distinguish between disease-causing and non-disease-causing mutations. Sci Rep. 2017 Aug 15;7(1):8237. doi: 10.1038/s41598-017-08419-7.
Rare disruptive variants in the DISC1 Interactome and Regulome: association with cognitive ability and schizophrenia.
Shaolei Teng, Pippa A Thomson, Shane McCarthy, Melissa Kramer, Stephanie Muller, Jayon Lihm, Stewart Morris, DC Soares, William Hennah, Sarah Harris, Luiz Miguel Camargo, Vladislav Malkov, Andrew M McIntosh, J Kirsty Millar, DH Blackwood, Kathryn L Evans, Ian J Deary, David J Porteous, W Richard McCombie. Rare disruptive variants in the DISC1 Interactome and Regulome: association with cognitive ability and schizophrenia. Molecular Psychiatry, 2017.
Disrupted-in-Schizophrenia-1 (DISC1) protein disturbs neural function in multiple disease-risk pathways
Lisha Shao, Binyan Lu, Zhexing Wen, Shaolei Teng, Lingling Wang, Yi Zhao, Liyuan Wang, Koko Ishizuka, Xiufeng Xu, Akira Sawa, Hongjun Song, Guoli Ming, Yi Zhong. Disrupted-in-Schizophrenia-1 (DISC1) protein disturbs neural function in multiple disease-risk pathways. Hum Mol Genet. 2017 Jul 15;26(14):2634-2648. doi: 10.1093/hmg/ddx147.
The essential requirement of an animal heme peroxidase protein during the wing maturation process in Drosophila
Bailey D, Basar MA, Nag S, Bondhu N, Teng S, Duttaroy A. The essential requirement of an animal heme peroxidase protein during the wing maturation process in Drosophila. BMC Dev Biol. 2017 Jan 11;17(1):1. doi: 10.1186/s12861-016-0143-8.
RNA-Seq in Schizophrenia
Xin Li, Shaolei Teng. RNA-Seq in Schizophrenia. (2016) Bioinformatics and Biology insights 9 (Suppl 1), 53
Genome-wide prediction and analysis of human tissue-selective genes using microarray expression data.
Shaolei Teng, Jack Y Yang and Liangjiang Wang. (2013) Genome-wide prediction and analysis of human tissue-selective genes using microarray expression data. BMC Medical Genomics, 6(Suppl 1):S10
Cancer missense mutations alter binding properties of proteins and their interaction networks
Hafumi Nishi, Manoj Tyagi, Shaolei Teng, Benjamin Shoemaker, Kosuke Hashimoto, Emil Alexov, Stefan Wuchty and Anna R. Panchenko. (2013) Cancer missense mutations alter binding properties of proteins and their interaction networks. PLOS ONE. 8(6): e66273
Predicting protein sumoylation sites from sequence features
Shaolei Teng, Hong Luo, Liangjiang Wang. (2011) Predicting protein sumoylation sites from sequence features. Amino Acids, 43(1):447-55.
Computational analysis of missense mutations causing Snyder-Robinson syndrome.
Zhe Zhang, Shaolei Teng, Liangjiang Wang, Charles E. Schwartz, Emil Alexov. (2010) Computational analysis of missense mutations causing Snyder-Robinson syndrome. Human Mutation, Sep;31(9):1043-9.
BIOINFORMATICS ANALYSIS OF RARE AMINO ACID SUBSTITUTIONS IN THE DISC1 INTERACTOME
S Teng. BIOINFORMATICS ANALYSIS OF RARE AMINO ACID SUBSTITUTIONS IN THE DISC1 INTERACTOME IMPLICATED IN SCHIZOPHRENIA. European Neuropsychopharmacology 29, S871-S872