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Sayan Nandi Picture
Faculty
Faculty

Sayan Nandi

Assistant Professor

sayan.nandi@howard.edu
202-806-6365

Department/Office

  • Anatomy

School/College

  • College of Medicine

Biography

Dr. Sayan Nandi received his Ph.D. degree from Albert Einstein College of Medicine, NY, where he studied the roles of hematopoietic cytokines in bone and brain development. He subsequently completed postdoctoral studies in Columbia University, NY, focusing on the roles of small noncoding RNAs in brain function, and in Einstein, where he studied fibroblast growth factor signaling in telencephalon development and in hippocampal neurogenesis and synaptogenesis. As a junior faculty in the research-track at Einstein, Dr. Nandi investigated the roles of microglia in synaptic remodeling and behavior and he further received two co-PI NIH pilot awards. This work also formally established the roles for Iba1, a protein that has long been known as a microglial marker, in normal brain function. As an Assistant Professor in the tenure-track at Howard University College of Medicine, Dr. Nandi focuses on the discovery of neural mechanisms as well as those related to neuroimmune interactions underlying neurodevelopmental and neuropsychiatric disorders, as well as neural injury.

Education & Expertise

Education

Ph.D.

Developmental and Molecular Biology
Albert Einstein College of Medicine
2009

Postdoctoral

Neuroscience
Columbia University

Postdoctoral

Neuroscience
Albert Einstein College of Medicine

Expertise

Research

Research

Specialty

Cell Signaling, Neurodevelopment, Microglia, Synapses, Behavior, Mouse Genetics, Biochemistry, Confocal Microscopy, Neurophysiology

Accomplishments

Accomplishments

(Selected Publications)

Chinnasamy, P., Casimiro, I., Riascos-Bernal, D.F., Venkatesh, S., Parikh, D., Maira, A., Srinivasan, A., Zheng, W., Tarabra, E., Zong, H., Jayakumar, S., Jeganathan, V., Pradan K., Aleman, J.O., Singh, R., Nandi, S., Pessin, J.E., Sibinga, N.E.S. (2023) Increased adipose catecholamine levels and protection from obesity with loss of Allograft Inflammatory Factor-1. Nature Communications. 14(1):38. PMID: 36596796 PMCID: PMC9810600

Lituma, P.J., Woo, E., O’Hara, B.F., Castillo, P.E., Sibinga, N.E.S., Nandi, S. (2021). Altered synaptic connectivity and brain function in mice lacking microglial adapter protein Iba1. Proceedings of the National Academy of Sciences. 118 (46) e2115539118 PMID: 34764226

Blackwood, C.A., Bailetti, A., Nandi, S., Gridley, T., Hébert, J.M. (2020). Notch dosage: jagged1 haploinsufficiency is associated with reduced neuronal division and disruption of periglomerular interneurons in mice. Frontiers in Cell and Developmental Biology. 8:113. PMID: 32161758 PMCID: PMC7054221

Nandi, S., Alviña, K., Lituma, P.J., Castillo, P.E., Hébert, J.M. (2018). Neurotrophin and FGF signaling adapter proteins, FRS2 and FRS3 regulate dentate granule cell maturation and excitatory synaptogenesis. Neuroscience. 369:192-201. PMID: 29155277 PMCID: PMC5766409

Nandi, S., Gutin, G., Blackwood, C.A., Kamatkar, N.G., Lee, K.W., Wang, F., Fishell, G., Goldfarb, M., Hébert, J.M. (2017). FGF-dependent, context-driven role for FRS adapters in the early telencephalon. Journal of Neuroscience. 37(23):5690-5698. PMID: 28483978 PMCID: PMC5469306

Nandi, S., Chandramohan, D., Fioriti, L., Melnick, A.M., Hébert, J.M., Mason, C.E., Rajasethupathy, P., Kandel, E.R. (2016). Roles for small non-coding RNAs in silencing of retrotransposons in the mammalian brain. Proceedings of the National Academy of Sciences. 113(45):12697-12702. PMID: 27791114 PMCID: PMC5111663