Doctor of Philosophy (Ph.D.)
Chemistry
Georgia Institute of Technology
1999
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Faculty
Faculty
Jason Shastri Matthews, Ph.D.
Professor
Department/Office
- Chemistry
School/College
- College of Arts & Sciences
Biography
Jason S. Matthews is currently a Professor of Chemistry and the Chair of the Natural Science Division (NSD) at Howard University. He received his B.S in chemistry from Howard University and his Ph.D. from The Georgia Institute of Technology. He worked as a senior chemist in the Catalyst Skills Center at the Union Carbide Corporation in Charleston, WV before joining the faculty at Howard University in 2001. His research interests include:
- Synthesis and evaluation of MOCVD precursors for use in the growth of materials
- Allosteric effectors for use with hemoglobin
- Polymerization catalysis
Education & Expertise
Education
Bachelor of Science (B.S.)
Chemistry
Howard University
1994
Expertise
Materials Chemistry
Biomaterials
Organometallic Chemistry
Academics
Academics
Organic Chemistry
Physical Organic Chemistry
Advanced Organic Chemistry
Research
Research
Specialty
Organometallic Chemistry, Catalysis, MOCVD, Materials Chemistry, BiomaterialsFunding
Co-Principal Investigator: DOW Chemical DOW-SURE. $255,000. (submitted 8/2021). Funded for 4 years.
Principal Investigator: HCSC HUPUMMP. $1,500,000. (submitted 1/2019). Funded for 5 years.
Co-Principal Investigator: NIST "Professional Research Experience Program - Material Measurement Laboratory (PREP-MML). $1,490,000. (submitted 6/2012). Funded for 3 years.
Accomplishments
Accomplishments
Union Carbide Special Recognition Award (SRA) Dec. 2000
Union Carbide Stock Award (EOG), Aug. 2000
Molecular Design Institute Fellow, 1997 – 1999
Presidents Fellowship, GIT, 1994 – 1998
Publications and Presentations
Publications and Presentations
Design, Synthesis, and Evaluation of Allosteric Effectors for Hemoglobin
Design, Synthesis, and Evaluation of Allosteric Effectors for Hemoglobin
Sickle cell disease (SCD) is an inherited blood disorder caused by a point mutation in hemoglobin (Hb), the protein in the red blood cell (RBC) responsible for the transport of oxygen (O2) throughout the body. The mutation leads to the expression of sickle cell hemoglobin (HbS). Both Hb and HbS exist in equilibrium between oxygenated and deoxygenated forms; however, deoxygenated HbS can polymerize to form long fibers which distort the shape of RBCs into the characteristic sickled shape. The misshapen RBCs can obstruct blood vessels and capillaries, resulting in a vaso-occlusive crisis. Vaso-occulsion deprives tissues and organs of O2 and can cause intense pain which often results in hospitalization. Chronic organ damage is a major cause of reduced life expectancy for SCD patients.
Distorted zinc coordination polyhedra
A new metal–organic precursor for the chemical vapor deposition of zinc oxide thin films, [Zn(C9H16NO3)2], has been synthesized and characterized by 1H and 13C NMR spectroscopy, single-crystal X-ray diffraction and thermogravimetric analysis. The asymmetric unit of the title compound consists of two molecules (Z′ = 2), with different zinc coordination polyhedra. In one molecule, the metal atom is in a distorted trigonal–bipyramidal ZnN2O3 environment (τ5 = 0.192) with a long bond to an ether O donor atom [Zn—O = 2.727 (6) Å]. In the other, the Zn atom is in a distorted ZnN2O4 octahedral environment with long bonds to the ether O donors of both ligands [Zn—O = 2.514 (4) and 2.661 (4) Å; O—Zn—O = 82.46 (14)°]. The crystal structure features weak C—H⋯·O interactions.
Synthesis and Structural Characterization of β-Enaminoamide Zinc Complexes
Synthesis and Structural Characterization of β-Enaminoamide Zinc Complexes
Novel β-enaminoamide zinc complexes were synthesized by reacting N,N-diethy-3-(isobutylamino)-2-butenamide (1) and N,N-dimethy-3-(isobutylamino)-2-butenamide (2), with diethylzinc to afford the desired zinc bis (β-enaminoamidate) complexes 3 and 4. Compounds 3 and 4 were recrystallized to afford high-quality single crystals which were characterized by single-crystal x-ray diffraction.
Synthesis and Structural Characterization of β-Enaminoester Zinc Complexes
Synthesis and Structural Characterization of β-Enaminoester Zinc Complexes
β-Enaminoester zinc complexes were synthesized by reacting ethyl 3-N-(butylimino)-2-butenoate (1) and ethyl 3-N-(hexylimino)-2-butenoate (2), with diethylzinc to afford the desired zinc bis(β-enaminoesterate) complexes 3 and 4.
