NC Central University/Durham
Dr. Mildred A. Pointer serves as the Chairperson of the Department of Biology at Howard University. Dr. Pointer has been continually funded as a PI of projects since 2005, four years after joining the faculty at NCCU with the charge of establishing an independent research program. Since that time, individual projects have brought in over $5.3 million in directs and indirects and an additional $8 million in directs and indirects as multiple PI of a program grant. Her population studies project is in its fourth 5-yr cycle of funding.Office Location: Just Hall Room 130Office Telephone: (202) 806-6933
NC Central University/Durham
Wake Forest Univ/Winston-Salem
Stress and African American Male Predisposition for Kidney and Cardiometabolic DiseaseNIMHD U54 RCMI (Kumar, PI) 9/1/2017 – 8/31/2022The goal is to determine if there are sex differences in perceived racism/stress activation of the hypothalamuspituitary adrenal stress system in African American
Pointer MA, Hicks K, Williams-Devane C, Wells C, Greene N; Gender Differences in Preclinical Markers of Kidney Injury in a Rural North Carolina African American Cohort Front Public Health. 2015 Jan 26;3:7. doi: 10.3389/fpubh.2015.00007
Pointer MA, Eley S, Anderson L, Waters B, Royall R, Nichols S, Wells C; Differential Effect of RenalCortical and Medullary Interstitial Fluid Calcium on Blood Pressure Regulation in Salt-sensitiveHypertension Am J Hypertens. 2014 Dec 31. pii: hpu255.
Kitsy A, Carney S, Vivar JC, Knight MS, Pointer MA, Gwathmey JK, Ghosh S; Effects of leucine supplementation and serum withdrawal on branched-chain amino acid pathway gene and protein expression in mouse adipocytes; PLoS One. 2014 Jul 22;9(7):e102615.
Pointer MA, Yancey S, Abou-Chacra R, Petrussi P, Waters SJ, McClelland MK, State anxiety is associated with cardiovascular reactivity in young, healthy African Americans Int J Hypertension 2012; 2012:268013 ePub.
Pointer MA, Daumerie G, Bridges L, Yancey S, Howard K, Davis W, Huang P, Loscalzo J. Physiologic Stress Increases Renal Injury in eNOS Knockout Mice. Hypertension Research Hypertension Res 2012; 35(3):318-4.
Bridges L, Williams C, Pointer MA, Awumey E. Mesenteric Artery Contraction and Relaxation Studies Using Automated Wire Myography. Journal of visualized Experiments 2011.
Daumerie G, Toolan K, Toolan G, Bridges L, Yancey S, Davis W, Huang P, Loscalzo J., Pointer MA. The Effect of Salt on Renal Injury in eNOS-deficient Mice. Hypertension Res 2010 Feb;33(2):170-6.
Pointer MA, Livingston JN, Yancey S, McClelland MK, Bukoski RD. Psychosocial Factors Contribute to Resting Blood Pressure in African Americans 2008, Ethnicity & Disease 18:289-293
Eley S, Allen C, Williams C, Bukoski RD, Pointer MA, Action of Thiazide on Renal Interstitial Calcium. 2008 Am J Hypertension 21:814-819.
Maitland K, Bridges L, Davis W, Loscalzo J, Pointer MA. Different Effects of Angiotensin Receptor Blockade on End-organ Damage in Salt-dependent and -independent 2006 Circulation; 114:905-91.
Bátkai S, Pacher P, Osei-Hyiaman D, Radaeva S, Liu J, Harvey-White J, Offertáler L, Mackie K, Rudd MA, Bukoski RD, Kunos G Endocannabinoids acting at CB1 receptors regulate cardiovascular function in hypertension 2004; Circulation 110:1996-2002
Palmer CE, Rudd MA, Bukoski RD. Renal interstitial Ca2+ during sodium loading of normotensive and Dahl-salt hypertensive rats 2003; Am J Hypertens16:771-776.
Pamarthi MF, Rudd MA, Bukoski RD Normal perivascular sensory dilator nerve function in arteries of Zucker diabetic fatty rats 2002 Am J Hypertens15: 310-315.
Jones MA, Mendes L, Rudd MA, Russo G, Loscalzo J, Zhang Y-Y Serial noninvasive assessment of progressive pulmonary hypertension in a rat model A. J. Physiol 2002; 283:H364-H371.
Trolliet MR, Rudd MA, Loscalzo J. Oxidative stress and renal dysfunction in salt-sensitive hypertension. Kid Blood Press Res Kidney Blood Press Res 2001; 24: 116-123.
Eberhardt RT, Forgione MA, Cap A, Rudd MA, Trolliet MT, Heydrick S, Stark R, Klings ES, Moldovan N, Yaghoubi M, Goldschmidt P, Farber HW, Cohen R, Loscalzo J. Endothelial dysfunction in mild hyperhomocystemia JCI 2000;106:483-491.
Zai A, Rudd MA, Scribner AM, Loscalzo J. Cell-surface protein disulfide isomerase catalyzes transnotrosation and regulates intracellular transfer of nitric oxide. J. Clin Invest 1999; 103:393-399.
Rudd MA, Trolliet M, Hope S, Scribner AM, Daumerie G, Loscalzo J. Salt-induced hypertension in Dahl salt-resistant rats with inhibition of inducible nitric oxide synthase. Am J. Physiol 1999; 277:H732-H739.
Lui Z, Rudd MA, Freedman JE, Loscalzo J. S-transnitrosation reactions are involved in the metabolic fate and biological actions of nitric oxide. J. Pharm Exp Therapeut 1998; 284:526-534.
Schaub RG, Bree MP, Hayes LL, Rudd MA, Rabbani LE, Loscalzo J. Recombinant human macrophage colony stimulating factor reduces plasma cholesterol and carrageenan foam cell formation in Watanabe Heritable Hyperlipidemic rabbits. Arteriosclerosis Thromb 1994; 14:70-76
Rabbani LE, Johnstone MT, Rudd MA, Devine P, George D, Loscalzo J. PPACK attenuates plasmininduced changes in endothelial integrity. Thrombosis Res 1993; 70:425-436.
Rudd MA, George D, Johnstone MT, Moore RT, Collins L, Rabbani LE, Loscalzo J. Effect of thrombin inhibition on the dynamics of thrombolysis and on platelet function during thrombolytic therapy. Circ Res 1992; 70:829-834.
Rudd MA, Johnstone MT, Rabbani LE, George D, Ware JA, Loscalzo J. Thrombolytic therapy causes an increase in vascular permeability that is reversed by DDAVP. Circulation 1991; 84:2568-2573.
Johnstone MT, Andrews T, Ware TA, Rudd MA, George D, Weinstein M, Loscalzo J. Bleeding time prolongation with streptokinase and its reduction with DDAVP. Circulation 1990; 82:2142-2151.
Kuo PC, Weinfeld M, Rudd MA, Amarante P, Loscalzo J. Plasma membrane enrichment with cisunsaturated fatty acids enhances LDL metabolism in U937 monocytes. Arteriosclerosis 1990; 10:111-118.
Rudd MA, George D, Amarante P, Vaughan DE, Loscalzo J. The temporal effects of thrombolytic agents on platelet function in vivo and their modulation by prostaglandins. Circ Res 1990; 1175-1181.
Rudd MA, Plavin S, Hirsch AT, Ingelfinger, JR, Dzau VJ. Atrial natriuretic factor-specific antibody as a tool for physiologic studies. Circulation 1989; 65:1324-1329.
Kuo PC, Rudd MA, Nicolosi R, Loscalzo J. Effect of dietary fat saturation on low density lipoprotein degradation by mononuclear cells of cebus monkeys. Arteriosclerosis 1989; 9:919-927.
Stamler JS, Vaughan DE, Rudd MA, Mudge GH, Kirshenbaum J, Young P, Alexander RW, Loscalzo J. Frequency of hypercholesterolemia after cardiac transplantation. Am J Cardiol 1988; 62:1268-1272.
Loscalzo J, Freedman J, Rudd MA, Barsky-Vasserman I, Vaughan DE. Unsaturated fatty acids enhance low density lipoprotein uptake and degradation by peripheral blood mononuclear cells. Arteriosclerosis 1987; 7:450-455.
Rudd MA, Grippo RS, Arendshorst WJ. Acute renal denervation produces a diuresis and natriuresis in young SHR but not WKY rats. Am J Physiol 1986; 251:F655-F661.