Doctor of Pharmacy (D.Pharm.)
Pharmaceutics
University of the Western Cape, South Africa
1996
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Faculty
Faculty
Indiran Pather, D.Pharm
Chair and Professor, Department of Pharmaceutical Sciences
Department/Office
- Pharmaceutical Sciences
School/College
- College of Pharmacy
Biography
Indiran Pather, D.Pharm. is a professor in the College of Pharmacy and is currently the Chair of the Department of Pharmaceutical Sciences. He was born in South Africa where he obtained the B.Pharm and M.Pharm degrees. The research work for his D.Pharm degree was done at the University of Missouri – Kansas City and at the pharmaceutical company, Marion-Merrell Dow. The degree was awarded by the University of the Western Cape, South Africa.
Pather has extensive teaching experience both in South Africa and in the United States. He has also worked for 10 years in the US pharmaceutical industry, rising to the position of Director of Pharmaceutical Sciences. In South Africa, he initiated a fee-for-service to the pharmaceutical industry which involved undertaking research and developments projects for pharmaceutical companies.
Pather’s expertise is in novel delivery systems, particularly buccal and sublingual delivery. He is also proficient in tablet manufacturing, emulsion formulation, cosmetic formulation and development, and good manufacturing practices (GMP). Pather played the lead role in the development of two products currently on the US market. He has published several papers and book chapters and has co-edited a book, Oral Mucosal Drug Delivery and Therapy. He has 18 US patents to his credit.
Education & Expertise
Education
Master of Pharmacy (M.Pharm.)
Pharmaceutics
University of the Western Cape, South Africa
1989
Bachelor of Pharmacy (B.Pharm.)
Pharmacy
University of Durban-Westville
1976
Research
Research
Funding
Principal Investigator: Undisclosed pharmaceutical company grant of $65,000 for non-GMP development of a novel injection formulation of a new drug. 2011.
Publications and Presentations
Publications and Presentations
Oral Mucosal Drug Delivery and Therapy
Oral Mucosal Drug Delivery and Therapy
This volume provides a comprehensive overview of the current issues facing scientists working on delivering drugs locally and systemically via the membranes that line the mouth. The book describes the anatomical and physiological challenges of this route for drug delivery and how they impact the design of oral mucosal drug delivery systems. It also provides a detailed description of current oral mucosal drug delivery technologies that overcome these challenges alongside research, development and assessment methods.
Effect of Experimental Temperature on the Permeation of Model Diffusants Across Porcine Buccal Mucosa
The influence of experimental temperature on the permeability of model diffusants across porcine buccal mucosa was investigated in vitro. The permeability increased significantly as the experimental temperature was increased in increments of approximately 7°C. It was observed that the apparent permeability and temperature were related by an exponential relationship that conformed to the Arrhenius equation. Diffusants with higher lipophilicities--buspirone and bupivacaine--had lower activation energies for diffusion when compared to hydrophilic diffusants--antipyrine and caffeine. The activation energy for diffusion of the model diffusants decreased linearly with increasing distribution coefficients across porcine buccal mucosa.
Porcine buccal mucosa as in vitro model
Porcine buccal mucosa as in vitro model: effect of biological and experimental variables
Porcine buccal mucosa has been used as an in vitro model to assess the potential of delivering a molecule via the transbuccal route. However, permeation studies across porcine buccal mucosa show high variability due to various experimental and biological factors. The variability associated with the use of different mucosal regions, tissue storage conditions and tissue processing methods on drug permeation was investigated in this study.