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Dr. Fayuan Wen

Fayuan Wen, PHD (She/Her)

Assistant Professor

  • Biology
  • College of Arts & Sciences


Dr. Fayuan Wen is an Assistant Professor of Computational Biology within the Department of Biology. After receiving her PhD in Virology and Entomology from Chinese Academy of Forestry, she started her postdoctoral training in Cellular Biology and Bioinformatics at University of Guelph and Natural Resources of Canada. She then joined Howard University as a postdoc associate where she adeptly applies advanced computational biology techniques and biostatistical tools to biomedical and health research domains. Dr. Wen's expertise lies in the analysis of bioinformatics data from next-generation sequencing (NGS) such as RNA-seq and Whole Genome Sequencing (WGS). Her research trajectory encompasses diverse areas, including whole genome sequencing analysis of Sickle Cell Disease (SCD), investigations into gene regulation during host-virus interactions, cellular transcriptional responses to chemical treatments, and bioinformatics inquiries into overwintering insects.

Currently, Dr. Wen focuses on gene variant identification relevant to Iron Overload in Sickle Cell Disease, utilizing genome-wide association studies (GWAS) and machine learning-based Polygenic Risk Score Analysis. Additionally, her projects involve rigorous bioinformatics analysis of NGS data and biostatistical evaluations of electronic health record data, underscoring her multifaceted contributions to the field.

Education & Expertise


Postdoc Assoiciate

Bioinformatics and Virology
Howard University

Postdoctoral Fellow

Cellular Biology and Bioinformatics
University of Guelph and Natural Resources of Canada


Entomology and Virology
Chinese Academy of Forestry


Next-Generation Sequencing Analysis, GWAS, Sickle Cell Disease, HIV



CRN 82210 - BIOG 430-01 Biostatistics

CRN 82210 - BIOG 430-02 Biostatistics




My research interests lie at the intersection of computational analysis for Next-Generation Sequencing (NGS) data and substantial data mining in the field of biology.

Related Articles

  1. Afangbedji, Nowah, Namita Kumari, Sharmin F. Diaz, Fayuan Wen, James G. Taylor, Sergei Nekhai, and Marina Jerebtsova, 2023. Soluble urokinase-type plasminogen activator receptor in sickle cell disease–associated chronic kidney disease. Blood Advances. 7 (9), 1854-1857
  2. Namita Kumari, Asrar Ahmad, Clemilson Berto-Junior, Andrey Ivanov, Fayuan Wen, Sharmin Diaz, James G Taylor, Marina Jerebtsova, Sergei Nekhai, 2022. Antiviral Response and HIV-1 Inhibition in Sickle Cell Disease. Blood 140 (Supplement 1), 5387-5388
  3. Béliveau, Catherine, Patrick Gagné, Sandrine Picq, Oksana Vernygora, Christopher I. Keeling, Kristine Pinkney, Daniel Doucet, Fayuan Wen et al. 2022. The spruce budworm genome: Reconstructing the evolutionary history of antifreeze proteins. Genome Biology and Evolution 14(6), evac087
  4. Margaret A. Taub, Fayuan Wen Rasika A. Mathias et al, 2022. Genetic determinants of telomere length from 109,122 ancestrally diverse whole-genome sequences in TOPMed. Cell Genomics. 2(1)
  5. Fayuan Wen, Angela Rock, Juan Salomon-Andonie, James G. Taylor, Sergei Nekhai et al, 2020. Genome wide association analysis of iron overload in the trans-omics for precision medicine (TOPMed) sickle cell disease cohorts. Blood. Nov 5; 136 (Supplement 1): 52
  6. Fayuan Wen,  Najealicka Armstrong, Wangheng Hou, Ruth Cruz-Cosme, Lilian Akello Obwolo, Koko Ishizuka, Hemayet Ullah, Min-Hua Luo, Akira Sawa, and Qiyi Tang. 2019. Zika virus increases mind bomb 1 levels, causing degradation of pericentriolar material 1 (PCM1) and dispersion of PCM1-containing granules from the centrosome. Journal of Biological Chemistry.  294, 18742-18755
  7. Wangheng Hou, Ruth Cruz-Cosme, Fayuan Wen, Jin-Hyun Ahn, Inez Reeves, Min-Hua Luo, Qiyi Tang. 2018. Expression of human cytomegalovirus IE1 leads to accumulation of mono-SUMOylated PML that is protected from degradation by herpes simplex virus 1 ICP0. Journal of Virology. 92 (23) e01452-18
  8. Wangheng Hou, Ruth Cruz-Cosme, Najealicka Armstrong, Lilian Akello Obwolo, Fayuan Wen, Wenhui Hu, Min-Hua Luo, Qiyi Tang. 2017. Molecular cloning and characterization of the genes encoding the proteins of Zika virus. Gene. 628: 117-128
  9. Fayuan Wen, Sharon Hooey, Guido Caputo, Peter Krell, Basil Arif, Daniel Doucet, et al. 2015. Establishment of a cell line from the ash and privet borer beetle Tylonotus bimaculatus Haldeman and assessment of its sensitivity to diacylhydrazine insecticides. In Vitro Cell Dev Biol Anim. 51(9):905-914 This publication was highlighted by the Journal:
  1. Guoxing Quan, Ladd Tim, Jun Duan, Fayuan Wen, Daniel Doucet, Michel Cusson, Peter J. Krell. 2013. Characterization of a spruce budworm chitin deacetylase gene: stage-and tissue-specific expression, and inhibition using RNA interference. Insect Biochemistry and Molecular Biology 43:683-691
  2. Fayuan Wen, Yong-an Zhang, Liangjian Qu, Zhongqi Yang et al. 2009. Two new cell lines originated from the embryos of Clostera anachoreta (Lepidoptera: Notodontidae): characterization and susceptibility to baculoviruses. In Vitro Cell Dev Biol Anim. 45(8):409-413
  3. Huan Zhang, Yong-an Zhang, Qi-lian Qin, Yu-zhu Wang, Liangjian Qu, Xuan Li, Lin Miao, Fayuan Wen. 2007. Advances in establishment of insect cell lines. Acta Entomologica Sinca. 50(8):834-839
  4. Fayuan Wen, Yong-an Zhang, Yuzhu Wang,Xinming Yin. 2005. Advances in application of microsporidia to pest management. Plant Protection. 31(3):5-9