Reema Puri, Solomon A. Berhe and Emmanuel O. Akala. "pH-Sensitive Polymeric Nanoparticles Fabricated By Dispersion Polymerization for the Delivery of Bioactive Agents”. Pharmaceutical Nanotechnology, 2017, 5, 1-28
Oluwaseun Ogunwuyi, Namita Kumari, Kahli A. Smith, Oleg Bolshakov, Simeon Adesina, Ayele Gugssa, Winston A. Anderson , Sergei Nekhai and Emmanuel O. Akala. “Antiretroviral Drugs-Loaded Nanoparticles Fabricated by Dispersion Polymerization with Potential for HIV/AIDS Treatment” Infectious Diseases: Research and Treatment 2016, 9:21-32
Emmanuel O. Akala, Simeon Adesina and Oluwaseun Ogunwuyi. “Computer Optimization of Biodegradable Nanoparticles Fabricated by Dispersion Polymerization”. Int. J. Environ. Res. Public Health, 13 (1); 47- 63(2016).
Simeon K Adesina, Uchechukwu Ezeonyebuchi and Emmanuel O Akala. “The effect of formulation variables on drug loading of antitubercular drugs in nanoparticle formulations”. Materials Research Express, Volume 2, Number 9 (2015) 095403
Simeon K. Adesina and Emmanuel O. Akala. “Nanotechnology Approaches for the Delivery of Exogenous siRNA for HIV Therapy”. Mol. Pharmaceutics, 2015, 12 (12), pp 4175–4187
Oluwaseun Ogunwuyi, Simeon Adesina and Emmanuel O. Akala. D-optimal mixture experimental design for stealth biodegradable crosslinked docetaxel-loaded poly-ε-caprolactone nanoparticles fabricated by dispersion polymerization. Pharmazie 70: 165–176 (2015)
Kahli A. Smith, Xionghao Lin, Oleg Bolshakov, James Griffin, Xiaomei Niu, Dmytro Kovalskyy, Andrey Ivanov, Marina Jerebtsova, Robert E. Taylor, Emmanuel Akala, Sergei Nekhai. Activation of HIV-1 with Nanoparticle-Packaged Small Molecule Protein Phosphatase-1-Targeting Compound Scientia Pharmaceutica 2015; 83: 535–548
Simeon K. Adesina, Alesia Holly, Gabriela Kramer-Marek, Jacek Capala, Emmanuel O. Akala. Polylactide based Paclitaxel-loaded Nanoparticles Fabricated by Dispersion Polymerization: Characterization, Evaluation in Cancer Cell Lines, and Preliminary Biodistribution Studies. Journal of Pharmaceutical Sciences Volume 103, Issue 8, August 2014, Pages: 2546 – 2555
Simeon K. Adesina, S.A. Wight, Emmanuel O. Akala. Optimization of the fabrication of novel stealth PLAbased nanoparticles by dispersion polymerization using D-optimal mixture design. Drug Development and Industrial Pharmacy, Vol.40, No.11 (1 November 2014): 1547-1556.
Oleg Bolshakov and Emmanuel O. Akala. MS-Monitored Conjugation of Poly(ethylene glycol)Monomethacrylate to RGD Peptides. J. Appl. Polym. Sci. 2014, 131, 40385 - 40395
Akala EO, Okunola O. Novel stealth degradable nanoparticles prepared by dispersion polymerization for the delivery of bioactive agents Part I. Pharm Ind 2013;75(7):1191-1196.
Akala EO, Okunola O. Novel stealth degradable nanoparticles prepared by dispersion polymerization for the delivery of bioactive agents Part II. Pharm Ind 2013;75(8):1346-1352
Emmamuel O. Akala, Pornruedee Wiriyacoonkasem, and Gaofeng Pan. Studies on in vitro availability, degradation, and thermal properties of naltrexone-loaded biodegradable microspheres. Drug Development and Industrial Pharmacy, 37; 673-684 (2011)
E. O. Akala “Strategies for Transmembrane Passage of Polymer-Based Nanostructures” in Polymer-Based Nanostructures: Medical Applications. Pages 16-80. Pavel Broz (ed.) Royal Society of Chemistry Series 9: Series Editors: Harry Kroto, Paul O'Brien, and Harold Craighead Cambridge, UK 2010.
E. Akala, H. Wang, Adedayo Adedoyin. Disposition of Naltrexone after Intravenous Bolus Administration in Wistar Rats, Low Alcohol Drinking Rats and High Alcohol Drinking Rats Neuropsychobiology 2008;58:81-90
W. Yin, E. Akala, and R. Taylor, Design of naltrexone-loaded hydrolyzable crosslinked nanoparticles. International Journal of Pharmaceutics, 244(1-2); 9-19(2002)
R. Groning, S. Weyel, E. Akala, E. Minkow and N. Lambow, “Computer-Controlled Release ofOxprenolol from Capsules Using Gas Producing Cells and Electronic Circuits”, Pharmazie 54(7); 510-513(1999)
E. O. Akala, P. Kopeckova and J. Kopecek, Novel pH Sensitive Hydrogels with Adjustable Kinetics of Swelling. Biomaterials 19; 1037 - 1047(1998).
E. O. Akala, Hydrolysis of Linear Copolymers with Pendant N, O-diacyhydroxylamine Moieties, Pharm. Pharmacol Lett. 8(3); 129-132(1998)
Cyprian O. Onyeji, Adebola O. Osilana, Festus A. Ogunbona and Emmanuel O. Akala, Chloroquine Bioavailability Following Rectal Administration in Man. Eur. J. Pharm. Biopharm. 42; 204-207(1996)
E. O. Akala and R .Groning. Studies on the characteristics of some rectal absorption enhancers using three-dimensional solubility parameters. Pharm. Res. 12(9);S-291(1995).
Book Chapter: Emmanuel O. Akala “Chapter 7.3: Effect of Packaging on Stability of Drugs and Drug Products” in Pharmaceutical Manufacturing Handbook: Regulations and Stability (2008). Edited by Shayne Cox Gad. Published by John Wiley & Sons, Inc. Hoboken, NewJersey. ISBN: 978-0-470-25959-7
Book Chapter: Akala, E. O. “Oral Controlled Release Solid Dosage Forms” in Theory and Practice of Contemporary Pharmaceutics, Edited by Tapash K. Gosh and Bhaskara R Jasti (CRC Press LLC, Boca Raton, FL). (ISBN: 0415288630, March 1, 2005), pp. 333 - 366
Emmanuel O. Akala, Gerunda B. Hughes and Tracey L. Rogers “Reinforcing concepts by studying experts: an integrated approach to the teaching of pharmaceutics” Journal of Pharmacy Teaching 11(2); 13-33 (2004)
Patent:(1). E. Akala, S. Adesina, Biodegradable Stealth Polymeric Particles Fabricated Using the Macromonomer Approach by Free Radical Dispersion Polymerization. United States Patent Application Publication Number US 2012/0129797 A1. Publication Date: 2012 (Already granted by the Patent Office).
Patent:Akala, E., Okunola, A., Stealth Polymeric Particles for Delivery of Bioactive and Diagnostic Agents. United States Patent Application Publication Number US 2012/0129798 A1. Publication Date: (2012)). (Already granted by the Patent Office).
Patent:Jindrich Kopecek, Pavla Kopeckova, Emmanuel O. Akala, Ping-Yang Yeh, and Karel Ulbrich (Inventors). Patent (1998): “Novel pH-Sensitive Hydrogels with Adjustable Swelling Kinetics for Colon-Specific Delivery of Peptides and Proteins” Patent Number: WO9801421 (Already granted by the Patent Office).
The publications and patents shown above are selected from several publications.
Emmanuel O. Akala and Simeon K. Adesina, “Fabrication of polymeric core-shell nanostructures” in Nanoscale Fabrication, Optimization, Scale-up and Biological Aspects of Pharmaceutical Nanotechnology 2017, Alexandru Mihai Grumezescu (ed.) Chapter 1 pp 1-49
Reema Puri, Simeon Adesina, Emmanuel Akala Cellular uptake and cytotoxicity studies of pHresponsive polymeric nanoparticles fabricated by dispersion polymerization J Nanosci Nanomed. 2(1):1-18 (2018)
Funmilola A. Fisusi and Emmanuel O. Akala. Drug Combinations in Breast Cancer Therapy. Pharmaceutical Nanotechnology, 2019, 7, 3- 23
Yvonne Abbey Berko and Emmanuel O. Akala. Computer Optimization of Stealth Biodegradable Polymeric Dual-Loaded Nanoparticles for Cancer Therapy using Central Composite Face-Centered Design. Pharmaceutical Nanotechnology, 2020, 8, 108-132
Funmilola Fisusi, Nailah Brandy, Jingbo Wu and Emmanuel O. Akala. Studies on Polyethylene Glycol-Monoclonal Antibody Conjugates for Fabrication of Nanoparticles. J Nanosci Nanomed Vol.4 No.2, 2020, 1-9
Anthony Hickey, Emmanuel Akala, Lawrence Block, John Hammond, Munir Hussain, Brent Kleintop, Nancy Lewen, June Liang, Jolyon Mitchell, Norbert Maurer, Myke Scoggins, Timothy Shelbourn, Thomas Tice, Katherine Tyner, Eloise Welfare (All members of the Joint Subcommittee of the United States Pharmacopeia Expert Committees on Dosage Forms, Chemical Analysis, Physical Analysis, and Excipients; and Kahkashan Zaidi, United States Pharmacopeia. Perspectives on Quality Attributes of Drug Products Containing Nanomaterials. Pharmaceutical Technology, Volume 2019 Supplement, Issue 5, pg 12–15 (Pharmaceutical Technology APIs, EXCIPIENTS, AND MANUFACTURING 2019 PharmTech.com).