Biography

Our lab is focused on understanding the role of inflammatory mediators on renal function and blood pressure regulation in acute and chronic models of hypertension. Research efforts are particularly devoted to the understanding of how inflammatory mediators regulate the expression of transport proteins along the nephron and increase fluid reabsorption. We are also investigating the migration of inflammatory mediators into the kidney to cause glomerular damage and the decrease of kidney function.  Our laboratory is also interested in how inflammatory mediators influence renal function during obesity, diabetes and severe food restriction.  We utilize a wide range of experimental techniques including radiotelemetry, measurement of renal blood flow, glomerular filtration rate, metabolic studies, biochemical assays, western blotting and quantitative reverse transcription PCR. The goal of our research is to provide translational approaches for the treatment of metabolic diseases and prevention of kidney disease.

I serve as the co-director of the Howard University Research Centers at Minority Institutions Professional Development component, co-director of the Georgetown-Howard Universities Centers for Clinical and Translational Science TL1 program.  I also serve as the Institutional Coordinator for the Howard University Leadership Alliance Summer Research Programs.  

Bibliography:

https://www.ncbi.nlm.nih.gov/myncbi/dexter.lee.1/bibliography/public/