Sudha Sharma
Professor
Department/Office
- Biochemistry
School/College
- College of Medicine
Additional Positions
-
Interim DirectorHuman Genome Center
Biography
Dr. Sudha Sharma is Professor of Biochemistry and Molecular Biology and Interim Director of the National Human Genome Center at Howard University College of Medicine. Her research focuses on understanding how cells maintain genomic stability and how defects in DNA repair pathways contribute to cancer, aging, and other human diseases. An NIH- and NSF-funded investigator, Dr. Sharma is recognized for her work on DNA helicases and other genome maintenance proteins that safeguard the integrity of the genome.
Dr. Sharma's laboratory investigates the molecular mechanisms by which mammalian cells respond to DNA damage and replication stress, with a particular emphasis on DNA repair and genome stability pathways. Her research seeks to understand how dysfunction of these pathways contributes to cancer susceptibility and age-related disease, and how insights into these mechanisms may inform future approaches to disease prevention and treatment.
As Interim Director of the National Human Genome Center, Dr. Sharma provides leadership for initiatives that advance genomics research and foster interdisciplinary collaboration. She is committed to strengthening research excellence and expanding opportunities for scientific discovery and innovation at Howard University.
Prior to joining Howard University in 2011, Dr. Sharma held a faculty appointment at the City University of New York. She earned her Ph.D. in Biochemistry from Banaras Hindu University and completed postdoctoral training at the National Institute on Aging, National Institutes of Health, under the mentorship of Dr. Robert Brosh. She also conducted research at Harvard Medical School in the laboratory of Dr. Bruce Yankner. Dr. Sharma received tenure at Howard University in 2014 and was promoted to Full Professor in 2019.
An active contributor to the scientific community, Dr. Sharma serves on review panels for national and international funding agencies and on editorial boards of scientific journals. She teaches medical and graduate students and has devoted her career to mentoring the next generation of scientists, including graduate students, postdoctoral fellows, undergraduate researchers, and aspiring young scientists. Through her research, teaching, and service, she is committed to fostering scientific excellence and preparing future leaders in biomedical research.
Education & Expertise
Education
Ph.D
Banaras Hindu University
1998
Expertise
Biochemistry, molecular and cell biology, genomics
Genome Maintenance Mechanisms, DNA Damage and Repair, Cancer Susceptibility, and Aging
Dr. Sharma's expertise lies in DNA repair, genomic stability, cancer biology, aging, and genome maintenance. Her laboratory investigates how mammalian cells respond to DNA damage and replication stress, with a particular focus on DNA helicases and other proteins that preserve genome integrity. Research in the laboratory combines molecular, cellular, biochemical, and genomic approaches to understand mechanisms underlying cancer susceptibility and age-related disease. By elucidating the pathways that maintain genome stability, her work aims to advance knowledge of disease mechanisms and identify opportunities for improved prevention and therapeutic strategies.
Academics
Academics
Medical Course- Molecules and Cells-Unit 1a (Course Coordinator)
Graduate Courses- Biochemistry and Moleular Biology
Undergraduate Course-Bio319
Research
Research
Specialty
DNA Damage and Repair, Genomic Stability, Cancer and Aging ResearchFunding
Research in the Sharma Laboratory has been supported by the National Institutes of Health (NIH), the National Science Foundation (NSF), the Canadian Institutes of Health Research (CIHR), and other collaborative research programs.
Group Information
The Sharma Laboratory investigates the molecular mechanisms that maintain genome integrity and safeguard cells from DNA damage. Genome maintenance pathways are essential for preventing the accumulation of genetic alterations that contribute to cancer, aging, and other human diseases. Our research seeks to understand how these pathways function under normal physiological conditions and how their disruption promotes disease development.
A major focus of our work is the study of DNA helicases and other proteins involved in DNA repair, DNA replication, transcription, and genome stability. We examine how these proteins respond to DNA damage and replication stress, and how defects in their function contribute to cancer susceptibility, genomic instability, and age-related disease. Particular emphasis is placed on understanding the biological functions of RecQ-family helicases, especially RECQ1 (RECQL or RECQL1) and their roles in maintaining cellular and organismal health.
Current areas of investigation include:
• Mechanisms of genome maintenance and DNA repair
• DNA helicases in genome stability and human disease
• Cellular responses to DNA damage and replication stress
• Cancer susceptibility and cancer-predisposing syndromes
• Genome instability in aging and age-related disease
• Transcriptional and genomic regulation by DNA repair proteins
• Molecular pathways linking DNA repair defects to carcinogenesis
Our laboratory integrates molecular, cellular, biochemical, and genomic approaches to address fundamental questions in genome biology and human disease. Through these studies, we seek to advance understanding of disease mechanisms and identify pathways that may inform future strategies for cancer prevention and therapeutic intervention.