See all Profiles
Head shot Dr. Baskaran
Faculty
Faculty

Padmamalini Baskaran, Ph.D.

Assistant Professor - Tenure Track

  • Pharmaceutical Sciences
  • College of Pharmacy

Biography

Padmamalini Baskaran is an Assistant Professor in the Department of Pharmaceutical Sciences at Howard University College of Pharmacy in Washington, D.C. She earned her Bachelor's and Master of Pharmacy degrees in India, specializing in Quality Assurance, and completed her Ph.D. at Karl Franzens University of Graz, Austria, where she investigated the enzyme soluble Guanylyl Cyclase (sGC).

Following her doctoral work, Dr. Baskaran discovered her passion for teaching and research. At the University of Wyoming School of Pharmacy, she taught pharmacology, sterile products, and pharmaceutical calculations to Pharm.D. students. She also delivered physiology and anatomy lectures to medical students through the Washington, Wyoming, Alaska, Montana, and Idaho Regional Medical Education Program (WWAMI). Since joining Howard University in 2021, she has taught Structure and Functions in Therapeutics and Pharmacological Therapeutics, mentored students in research electives, and coordinated Applications for Pharmacy Practice (V) for third-year students. Her teaching philosophy emphasizes active, student-centered learning that fosters critical thinking, self-confidence, and professional communication skills, while integrating basic science with clinical therapeutics.

Dr. Baskaran’s research career began with an exploration of sGC in cardiovascular health, including its roles in vasodilation, platelet function, and nitrate tolerance. As a postdoctoral fellow and research assistant professor, she advanced studies on Cyclophilin A in platelets and vascular inflammation. Later, at the University of Wyoming, she made seminal contributions in obesity research, demonstrating that TRPV1 activation by capsaicin counters diet-induced obesity by promoting thermogenesis and browning of adipose tissue, and investigated topical TRPV1 agonists for diabetic neuropathy.

At Howard University, her research program centers on therapeutic discovery and rigorous preclinical investigation of innovative TRPV1-targeted strategies. She is developing and evaluating novel capsaicin-based formulations for obesity and non-alcoholic fatty liver disease, and conducting mechanistic preclinical studies to determine the therapeutic efficacy of empagliflozin combined with nitrovasodilators in HFrEF. In parallel, her laboratory is exploring TRPV1 agonists as a first-in-class therapeutic approach for triple-negative breast cancer, with particular emphasis on high-risk populations.

She also collaborates with a professor at Auburn University to develop site-specific capsaicin implant delivery systems to evaluate their anti-obesity potential in mouse models, thereby advancing precision-targeted therapeutic strategies. Her work integrates molecular pharmacology, translational models, and disease-focused drug development to bridge bench-to-bedside gaps. She has received multiple honors, including the AACP New Investigator Award, the Summer Research Grant from the Howard University Center for Women, Gender and Global Leadership, and the HUCOP Seed Grant. She actively pursues federal and RCMI funding to advance her discovery-driven and preclinical translational research program. She currently serves as Guest Editor for a Special Issue of Current Issues in Molecular Biology on the Mechanisms and Pathophysiology of Obesity (Impact Factor 4.8), published by the Multidisciplinary Digital Publishing Institute (MDPI).

Dr. Baskaran is deeply committed to excellence in pharmacology education, with a strong emphasis on helping students understand, retain, and apply core pharmacologic principles. Her teaching approach integrates clinically rich, case-based examples that connect mechanisms of action, therapeutic decision-making, and adverse effect management to real-world patient care. By anchoring foundational knowledge in practical scenarios, she reinforces the critical importance of pharmacologic reasoning in addressing complex health challenges. Her dedication to teaching has been recognized with the Howard University College of Pharmacy (HUCOP) Teacher of the Year Award in 2023 and consecutive Excellence in Teaching Awards for the 2023–2024 and 2024–2025 academic years. She was honored with the Faculty of the Year Award in 2024 and 2025, presented by the Howard University College of Pharmacy Student Council (CPSC) during the HUCOP Apothecary Brunch.

Beyond the classroom, she is dedicated to mentoring students in research, guiding them toward meaningful scholarly experiences, competitive scholarships, conference presentations, and professional development opportunities. She fosters critical thinking, scientific curiosity, and confidence, preparing trainees to translate knowledge into impactful practice and discovery.

At Howard University, she values collaborative engagement with colleagues to advance the institution’s mission of training scholars and healthcare professionals committed to addressing important health problems through innovation, leadership, and service. 

Education & Expertise

Education

Doctor of Natural Sciences (Ph.D.)

Pharmacy (Molecular Pharmacology and Physiology)
University of Graz, Austria
2002

Master of Pharmacy (M. Pharm)

Quality Assurance
S.N.D.T. Women’s University, Mumbai
1996

Bachelor of Pharmacy (B. Pharm)

Pharmaceutical Sciences
Madras Medical College
1994

Academics

Academics

Pharmacological Therapeutics I

Pharmacological Therapeutics II

Applications for Pharmacy Practice V/Applications for Pharmacy Practice A

Research Elective (Fall/Spring)

Applications for Pharmacy Practice VI/ APP B

Research

Research

Funding

Principal Investigator: American Association of Colleges of Pharmacy New Investigator Award (AACP NIA) (Extramural). Title: Mitochondrial Quality Control and Fatty Liver Disease. Sponsor: American Association of Colleges of Pharmacy. $8,000. 2022 – 2023.

Principal Investigator: Howard University Summer Research Grant by the Center for Women, Gender, and Global Leadership (CWGGL)(Intramural). Title: Analysis of the effect of Non-Alcoholic Fatty Liver Disease in Murine Diet-Induced ObesityModel by Invasive and Non-Invasive diagnostic methods. Sponsor: Howard University Summer Research Grant by the Center for Women, Gender and Global Leadership (CWGGL). $4,000. June 2022-August 2022.

Principal Investigator: College of Pharmacy Research Seed Grant (CPRSG). Title: Enhanced efficacy of the combination of empagliflozin and hydralazine-isosorbide dinitrate in Heart Failure with reduced ejection fraction in the African American population. Sponsor: The Howard University College of Pharmacy. $5,000. April 2023-March 2024.

Accomplishments

Accomplishments

Faculty of the year award, Howard University College of Pharmacy Student Council (CPSC), 2024 & 2025

Excellence in Teaching Award, Presented by the Dean of the HU College of Pharmacy, 2023/2024 & 2024/2025

Teacher of the year award, presented by the Dean of the Howard University College of Pharmacy, 2022/2023

Special invitee to Governor Mead’s Technology Summit held in Jackson Hole, WY, Sept. 2017

Austrian Academic Exchange Scholarship for Ph. D., a research study in Austria, 1999-2002

Publications and Presentations

Publications and Presentations

Retrospective Evaluation of Metabolic Syndrome’s Role in Breast Cancer Outcomes in Black Women

Retrospective Evaluation of Metabolic Syndrome’s Role in Breast Cancer Outcomes in Black Women

Metabolic Syndrome (MS) is a cluster of chronic conditions characterized by the co-occurrence of at least three out of five clinical risk factors: central obesity, hyperglycemia, hypertension, elevated circulating triglycerides, and low high-density lipoprotein (HDL) levels. MS is a well-established precursor to cardiovascular disease and type 2 diabetes mellitus (DM), but emerging evidence also links MS-related pathways, particularly those involving obesity and hyperglycemia, to increased breast cancer (BC) risk and tumor progression. Despite this growing body of literature, there remains a significant gap in understanding the interplay between MS components and BC progression among Black women, a population disproportionately affected by both MS and adverse breast cancer outcomes.

Resmetirom and beyond

Resmetirom and beyond: A new era in MASLD therapeutics

Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), has emerged as the most prevalent chronic liver condition globally, affecting nearly 100 million individuals in the United States alone. The recent reclassification of NAFLD to MASLD and non-alcoholic steatohepatitis (NASH) to metabolic dysfunction-associated steatohepatitis (MASH) reflects a paradigm shift in understanding the metabolic underpinnings of this disease.

Obesity-Induced MASLD Is Reversed by Capsaicin via Hepatic TRPV1 Activation

Obesity-Induced MASLD Is Reversed by Capsaicin via Hepatic TRPV1 Activation

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a progressive liver disorder associated with metabolic risk factors such as obesity, type 2 diabetes, and cardiovascular disease. If left untreated, the accumulation of excess hepatic fat can lead to inflammation, fibrosis, cirrhosis, hepatocellular carcinoma, and ultimately liver failure. Capsaicin (CAP), the primary pungent compound in chili peppers, has previously been shown to prevent weight gain in high-fat diet (HFD)-induced obesity models. In this study, we investigated the potential of dietary CAP to prevent HFD-induced MASLD. Methods: C57BL/6 mice were fed an HFD (60% kcal from fat) with or without 0.01% CAP supplementation for 26 weeks. We evaluated CAP’s effects on hepatic fat accumulation, inflammation, and mitochondrial function to determine its role in preventing MASLD.